Ukr.Biochem.J. 2021; Том 93, № 1, січень-лютий, c. 5-17

doi: https://doi.org/10.15407/ubj93.01.005

Віропорини коронавірусів: структура і функції

25.02.2021   Uncategorized   No comments

І. А. Залоїло1, Ю. П. Рудь2, О. В. Залоїло2, Л. П. Бучацький2

1Національний університет біоресурсів і природокористування України, Київ;
2ННЦ «Інститут біології та медицини», Київський національний університет імені Тараса Шевченка, Україна;
e-mail: iridolpb@gmail.com

Отримано: 08 липня 2020; Затверджено: 17 грудня 2020

Віропорини беруть участь у вірусному патогенезі, відіграють важливу роль у морфогенезі віріонів та забезпечують їх вивільнення з інфікованої клітини. Ці протеїни є потенційно перспективними як можливі мішені для регулювання репродукції вірусів. В огляді узагальнено літературні дані щодо сучасного розуміння функціонування віропоринів. Особливу увагу зосереджено на специфічних структурних особливостях, які обумовлюють функціональну спроможність цих протеїнів. Розглянуто основні принципи локалізації віропоринів у клітині та їх вплив на життєвий цикл коронавірусів.

Ключові слова: , , , , , ,

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