Ukr.Biochem.J. 2021; Том 93, № 1, січень-лютий, c. 18-29

doi: https://doi.org/10.15407/ubj93.01.018

Замкнене коло між оксидативним стресом та цитокіновим штормом у патогенезі гострого респіраторного дистрес-синдрому за зараження COVID-19

25.02.2021   Uncategorized   No comments

G. H. Meftahi1, Z. Bahari1,2, Z. Jangravi3,4*, M. Iman3,5

1Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran;
2Department of Physiology and Medical Physics, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran;
3Nanobiotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran;
4Department of Biochemistry, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran;
5Department of Pharmaceutics, Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran;
*e-mail: jangraviz89@gmail.com

Отримано: 31 серпня 2020; Затверджено: 17 грудня 2020

На початку грудня 2019 року в місті Ухань провінції Хубей (Китай) розпочався спалах коронавірусної хвороби 2019 (COVID-19). З того часу пандемія значно поширилась і перетворилась на велику світову кризу через швидке розповсюдження коронавірусу. Основною причиною летальності вважають гострий респіраторний дистрес-синдром (ARDS – acute respiratory distress syndrome) – синдром гострої дихальної недостатності. Цитокіновий шторм та оксидативний стрес є основними гравцями за розвитку ARDS під час респіраторних вірусних інфекцій. У цьому огляді обговорено молекулярні механізми формування фатального замкненого кола між оксидативним стресом та цитокіновим штормом у разі зараження COVID-19 та  описано чому старіння може сприя­ти виникненню такого кола.

Ключові слова: , , ,

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