I. I. Ilkiv, R. B. Lesyk, O. Ya. Sklyarov

Danylo Halytsky Lviv National Medical University, Lviv, Ukraine;
e-mail: ira9ilkiv@gmail.com

The aim of investigation was to compare the action of novel 4-thiazolidinone derivaties (compounds Les-5054 and Les-5055) toward parameters of nitroso-oxidative processes in mucous membrane of small intestine (MMSI) in rats on the background of indomethacin induced injury. The activity of nitric oxide synthases, myelopeoxidase, content of NO, and parameters of lipoperoxidation processes were measured in MMSI and the level of H₂S and L-arginine in blood serum. Administration of indomethacin caused significant destructive damages in distal part of small intestine and increase in activity of inducible nitric oxide synthase (iNOS) and intensity of lipoperoxidation  processes in comparison to control were observed. Also indomethacin injection was accompanied by decrease of H₂S and L-arginine level in blood serum. Administration of 4-thiazolidinone derivaties on the background of indomethacin induced injury reduce the activity of iNOS, myeloperoxidase, intensity of lipid peroxidation and increase generation of H₂S, that may be linked with the structure of this compounds. However compound Les-5054 showed more significant cytoprotective effect and antioxidant properties than compound Les-5055. Thus, the novel 4-thiazolidinone derivaties led to reduce of nitroso-oxidative processes caused by administration of NSAIDs.