Ukr.Biochem.J. 2018; Том 90, № 1, січень-лютий, c. 3-24

doi: https://doi.org/10.15407/ubj90.01.003

Біосинтез оксиду азоту з L-аргініну. Особливості утворення та функціональна роль NO в мітохондріях

19.02.2018   Без категорії   No comments

Г. В. Данилович, Т. В. Богач, Ю. В. Данилович

Інститут біохімії ім. О. В. Палладіна НАН України, Київ;
e-mail: danylovych@biochem.kiev.ua

В огляді проаналізовано сучасні дані щодо біохімічних закономірностей біосинтезу оксиду азоту із L-аргініну в клітинах ссавців за нормоксичних умов. Розглянуто структуру та особливості регуляції ізоформ NO-синтази. Акценти зроблено на новітніх уявленнях про компартменталізацію в клітинах окремих ізоформ цього ензиму та можливості спрямованого транспорту оксиду азоту в судинній стінці. Центральне місце в огляді приділено питанням ендогенного утворення NO в мітохондріях та його вірогідному фізіологічному значенню. Подано і власні результати по ідентифікації оксиду азоту в мітохондріях гладенького м’яза матки, біохімічні характеристики цього процесу, обговорено можливу роль NO в регуляції транспорту Са2+ в мітохондріях.

Ключові слова: , , , , ,

Посилання:

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