Ukr.Biochem.J. 2013; Том 85, № 1, січень-лютий, c. 5-21

doi: http://dx.doi.org/10.15407/ubj85.01.005

Cфiнгозин-1-фосфат: розподіл, метаболізм і роль в регуляції клітинних функцій

В. І. Морозов1, Г. A. Сакута2, М. І. Калинський3

1Інститут еволюційної фізіології та біохімії ім. І. М. Сеченова РАН, Санкт-Петербург, Росія;
2Інститут цитології РАН, Санкт-Петербург, Росія;
3Кентский державний університет, Кент, США;
e-mail: vmorozov.g@gmail.com

В огляді проведено аналіз ролі сфінголіпідy сфiнгозин-1-фосфату (С1Ф) в регуляції  клітинних функцій і захисту клітин. С1Ф поряд з іншими сфінголіпідними метаболітами розглядають як внутрішньоклітинний другий месенджер і як позаклітиннy медіаторну молекулу. Описано продукцію та метаболізм С1Ф, клітинні рецептори та їх тканиннy специфічність. Показано значення тромбоцитів і еритроцитів крові в транспорті С1Ф. Встановлено, що гіпоксія індукує збільшення С1Ф, який через свої клітинні рецептори ініціює ланцюг цитопротектoрниx  подій. Наведені приклади цитопротекції пов’язані з кардiомiоцитами, клітинaми ендотелію та гладеньких м’язів. Розглянуто участь С1Ф у регуляції міграції клітин, міогенезy, контролю функцій скелетних м’язів. Представлені дані про те, що порушення балансу С1Ф може опосередковувати патологічні стани, що вказує на можливість використання системи С1Ф як реальної і ефективної мішені для фармакологічного впливу.

Ключові слова: , , , , ,


Посилання:

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