Ukr.Biochem.J. 2014; Том 86, №5, вересень-жовтень, c. 5-25

doi: http://dx.doi.org/10.15407/ubj86.05.005

Гідрогенсульфід: метаболізм, біологічне та медичне значення

Н. В. Заічко, А. В. Мельник, М. М. Йолтухівський,
О. С. Ольховський, І. В. Паламарчук

Вінницький національний медичний університет ім. М. І. Пирогова, Україна;
e-mail: nzaichko@mail.ru

Гідрогенсульфід (H2S) є сигнальною молекулою, яка активно синтезується в тканинах і бере участь у регуляції судинного тонусу, нейромодуляції, цитопротекції, в запаленні, апоптозі. В останні роки накопичились нові дані про метаболізм та функції H2S в організмі тварин та людини в умовах дії різних ендогенних та екзогенних чинників, у тому числі і лікарських засобів. У представленому огляді узагальнено інформацію про основні та альтернативні шляхи метаболізму H2S та їх регуляцію, особливості його транспортування, сигналінгу, біологічну роль, участь в розвитку патологічних станів. Наведено дані щодо вмісту H2S та активності H2S-синте­зуючих ензимів у різних органах, щодо впливу H2S на процеси зсідання крові та агрегації тромбоцитів з урахуванням результатів власних досліджень. Запропоновано робочу класифікацію модуляторів обміну H2S, які використовуються в біології та медицині: 1) засоби, що підвищують вміст H2S у тканинах (неорганічні та органічні донори H2S; субстрати H2S-синтезуючих ензимів та їх деривати; засоби з ефектом вивільнення H2S; засоби, що містять кофактори та активатори H2S-синтезуючих ензимів; засоби, які інгібують утилізацію H2S); 2) засоби, що знижують вміст H2S у тканинах (специфічні та неспецифічні інгібітори H2S-синтезуючих ензимів); 3) засоби з невизначеним механізмом впливу на обмін H2S (окремі фармакологічні засоби). Показано, що перспективними засобами для корекції вмісту H2S у тканинах є вітамінно-мікроелементні та мікроелементні комплекси, які містять кофактори та активатори H2S-синтезуючих ензимів.

Ключові слова: , , , , ,


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