Ukr.Biochem.J. 2015; Том 87, № 6, листопад-грудень, c. 19-35

doi: http://dx.doi.org/10.15407/ubj87.06.019

Перепрограмування енергетичного метаболізму мітохондрій в злоякісних новоутвореннях

О. А. Капля1, Л. В. Сорокіна2, С. В. Хижняк3

1Інститут біохімії ім. О. В. Палладіна НАН України, Київ;
e-mail: kaplya@biochem.kiev.ua;
2ННЦ «Інститут біології», Київський національний університет імені Тараса Шевченка, Україна;
3Національний університет біоресурсів і природокористування України, Київ

В огляді наведено новітні уявлення про роль мітохондрій в забезпеченні життєздатності злоякісних клітин. Розглянуто питання про мітохондріальний контроль окисно-відновлювального гомеостазу клітин, сайти продукування мітохондріальних активних форм кисню (АФК) у внутрішній мембрані мітохондрій і системи антиоксидантного захисту. Проаналізовано особливості структурно-функціональної реорганізації мітохондрій в злоякісних новоутвореннях, механізми перепрограмування енергетичного метаболізму, підсилення продукування АФК, адаптації до умов гіпоксії та метаболічного стресу. На підставі даних літератури та проведених власних досліджень на перещеплених пухлинах дійшли висновку, що цитотоксична дія мітокану дихлорацетату натрію – інгібітора кінази піруватдегідрогенази – залежить від біологічних властивостей пухлин та глибини структурно-функціональної реорганізації мітохондрій. Дихлорацетат натрію ефективно гальмує ріст саркоми 37, однак не впливає на ріст та метастазування карциноми легені Льюїс.

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