Ukr.Biochem.J. 2016; Том 88, № 4, липень-серпень, c. 57-65

doi: http://dx.doi.org/10.15407/ubj88.04.057

QSAR дослідження та антимікробний потенціал 1,3-тіазолілфосфонієвих солей

20.09.2016   Без категорії   No comments

M. M. Труш1, В. В. Ковалішин1, В. M. Благодатний2, В. С. Броварець1,
С. Г. Пільо1, В. M. Прокопенко1, Д. M. Година1, Л. O. Метелиця1

1Інститут біоорганічної хімії та нафтохімії НАН України, Київ;
2Національна медична академія післядипломної освіти імені П. Л. Шупика, Київ, Україна;
*e-mail: maria@bpci.kiev.ua

Побудовано регресійні QSAR-моделі для прогнозу антимікробної активності нових похідних тіазолу. Сполуки з високою прогнозованою активністю були синтезовані та тестовані проти грибів та грампозитивних і грамнегативних бактерій. 1,3-тіазол-4-ілфосфонієві солі 4 та 5 виявили значну антибактеріальну та високу протигрибкову активність. Результати прогнозу корелюють з результатами експериментальних досліджень, що свідчить про високу прогнозуючу здатність створених QSAR моделей.

Ключові слова: , ,

Посилання:

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