Ukr.Biochem.J. 2018; Том 90, № 3, травень-червень, c. 5-16

doi: https://doi.org/10.15407/ubj90.03.005

Біохімічні механізми вільно-радикального ушкодження ядерного геному кадмієм

І. М. Трахтенберг1, Ю. І. Губський2, Є. Л. Левицький3, І. Ф. Бєленічев4

1Інститут медицини праці НАМН України, Київ;
2Інститут фармакології і токсикології НАМН України, Київ;
3Інститут біохімії ім. О. В. Палладіна НАН України, Київ;
e-mail: levitsky@biochem.kiev.ua;
апорізький державний медичний університет Міністерства охорони здоров’я України

Кадмій протягом багатьох років використовується в промисловості і сільському господарстві. Активне його застосування пов’язано з небезпекою для здоров’я людини, зважаючи на значний рівень токсичної дії на організм. Мета огляду – проаналізувати дані літератури і результати власних експериментальних досліджень, що стосуються біохімічних механізмів токсичної дії кадмію на ядерний хроматин клітин, передусім, печінки. На підставі цього аналізу підтверджено концепцію, згідно з якою токсичність кадмію визначається ушко­дженнями, спричиненими вільними радикалами, виникнення яких індукують іони токсиканту. Утворені при цьому реактивні види кисню є, самі по собі, активними ушкоджуючими агентами, що зумовлюють токсичні ефекти, в тому числі мутагенний, що призводить у кінцевому підсумку до апоптозу і загибелі клітини.

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