Ukr.Biochem.J. 2022; Том 94, № 1, січень-лютий, c. 75-85
doi: https://doi.org/10.15407/ubj94.01.075
Нові двоядерні комплекси ціанідів із гидроксиаміновим лігандом: Синтез, характеристика та можливості застосування
N. Korkmaz1*, Ş. A. Korkmaz2, Y. Ceylan3,
R. İmamoğlu3, A. S. Bülbül4, A. Karadağ5
1Department of Basic Sciences and Health, Hemp Institute, Yozgat Bozok University, Yozgat, Turkey;
2Department of Chemistry and Chemical Processing Technologies, Tunceli Vocational School, Munzur University, Tunceli, Turkey;
3Faculty of Science, Department of Molecular Biology and Genetics, Bartın University, Bartın, Turkey;
4Department of Biology, Faculty of Science and Arts, Kahramanmaraş Sütçü İmam University, Kahramanmaraş, Turkey;
5Department of Chemistry, Faculty of Arts and Sciences, Yozgat Bozok University, Yozgat, Turkey;
*e-mail: nesrinokumus@gmail.com
Отримано: 14 вересня 2021; Затверджено: 21 січня 2022
Метою цієї роботи було синтезувати комплекси ціанідів [Ni(Abut)Ni(CN)4]·8H2O (C1), [Cu(Abut)2Ni(CN)4]·7H2O (C2), [Zn(Abut)Ni(CN)4]·8H2O (C3) та [Cd(Abut)Ni(CN)4]·7H2O (C4) та дослідити їх антибактеріальну та цитотоксичну дію. Одержані комплекси вивчали методом мікрохвильового синтезу з використанням ІЧ- Фур’є спектроскопії та термічного аналізу. Досліджено антибактеріальну та цитотоксічну активність синтезованих комплексів. Встановлено, що розщеплення смуг коливання ціанідогруп в ІЧ-Фур’є спектрах C1-C4 вказує на наявність кінцевих ціаногруп. Антибактеріальну активність C1-C4 вивчали на дев’яти видах грам-негативних та шести грам-позитивних бактеріях. Найбільшу антибактеріальну активність комплексів спостерігали за концентрації 1000 мкг/мл. Цитотоксичну активність оцінювали з використанням клітинної лінії HeLa та МТТ-тесту. Виявлено, що досліджувані ціанідні комплекси знижують життєздатність клітин HeLa зі значеннями IC50 14,86; 6,5; 7,2 та 19,2 мкг/мл для комплексів C1, C2, C3 та C4, відповідно.
Ключові слова: антибактеріальна, клітини HeLa, комплекси цианідів, цитотоксична активність
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