Ukr.Biochem.J. 2014; Том 86, №1, січень-лютий, c. 5-20

doi: http://dx.doi.org/10.15407/ubj86.01.005

Кальпаїни: характеристика та роль за різних станів організму

02.06.2015   Uncategorized   No comments

М. Ф. Стародуб1, Л. М. Самохіна2, С. М. Коваль2, І. О. Снігурська2

1Національний університет біоресурсів і природокористування України, Київ;
e-mail: nikstarodub@yahoo.com;
2ДУ «Національний інститут терапії ім. Л. Т. Малої НАМН України», Харків;
e-mail: lub.samokhina@yandex.ua

Огляд присвячено кальпаїнам – сімейству цитоплазматичних кальційзалежних протеїназ з папаїноподібною активністю, які беруть участь у різноманітних процесах, що відбуваються в організмі: за вікових змін, у функціонуванні ендотелію та легеневої системи, регуляції апоптозу та некрозу, розвитку різних гіпометаболічних станів, гіпертензії, а також при діабеті, хронічній хворобі нирок і пухлинному рості. Дійшли висновку, що кальпаїни, спричиняючи обмежений протеоліз субстратів, відіграють важливу роль у реалізації широкого спектра біологічних явищ. Їх функціонування пов’язане з відповіддю на кальційзалежну сигналізацію. Пригнічення активності кальпаїнів сприяє гальмуванню розвитку дисфункції ендотелію, серцево-судинних ускладнень, формуванню структурних та функціональних змін у тканинах нирок, а також спричинює нейропротекторний ефект, запобігає саркопенії і послаблює запальні реакції, зумовлені гіпервентиляцією легенів.

Ключові слова: , , , , , , , , ,

Посилання:

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