Ukr.Biochem.J. 2019; Том 91, № 6, листопад-грудень, c. 86-95

doi: https://doi.org/10.15407/ubj91.06.086

Вплив селену і нано-селену на індуковану цисплатином нефротоксичність у щурів-альбіносів

M. M. A. Shafaee1, H. S. Mohamed2, S. A. Ahmed1, M. A. Kandeil3

1Chemistry Department, Faculty of Science, Beni-Suef University, Egypt;
2Research Institute of Medicinal and Aromatic Plants, Beni-Suef University, Egypt;
3Biochemistry Department, Faculty of Veterinary Medicine, Beni-Suef University, Egypt;
e-mail: husseinshaban@science.bsu.edu.eg

Отримано: 5 липня 2019; Затверджено: 18 жовтня 2019

Цисплатин широко використовується в хіміотерапії для лікування деяких форм раку, але його застосування обмежене через побічну нефротоксичну дію. Раніше було виявлено позитивний вплив селену на токсичність цисплатину у разі короткочасних введень, хоча рекомендована схема прийому цисплатину за хіміотерапії – це багаторазове введення кожні три або чотири тижні залежно від типу пухлини. Метою цього дослідження було вивчити ефект застосування селену або нано-селену на індуковану цисплатином нефротоксичність у щурів-альбіносів. Сорок щурів було розділено на чотири рівні групи. Упродовж експериментального періоду (70 днів) тваринам цих груп вводили: 1 (контроль) – фізіологічний розчин; 2 – цисплатин 6 мг/кг кожний 21-й день; 3 – цисплатин 6 мг/кг плюс в/м ін’єкція селену (у вигляді селеніту натрію) 0,1 мг/кг кожні 3 дні; 4 – цисплатин 6 мг/кг плюс в/м ін’єкція нано-селену 0,1 мг/кг кожні 3 дні. Показано, що селен або нано-селен виявляв антиоксидантний ефект за рахунок підвищення рівня антиоксидантних ензимів як у сироватці крові, так і в нирковій тканині. Разом з тим, у щурів, які отримували цисплатин протягом експериментального періоду, спостерігали також негативний вплив на функцію нирок через підвищення в сироватці крові концентрації сечовини і креатиніну та аномальні морфологічні зміни в тканині нирок.

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